<i>Cuminum cyminum </i>Linn (Apiaceae) extract attenuates MPTP-induced oxidative stress and behavioral impairments in mouse model of Parkinson’s disease
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چکیده
منابع مشابه
Arbutin attenuates behavioral impairment and oxidative stress in an animal model of Parkinson's disease
Objective: Arbutin has been shown to have antioxidant and free-radical scavenging properties. The aim of this study was to investigate the effects of arbutin administration on behavioral impairment, and oxidative and nitrosative stress in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced animal model of Parkinson’s disease (PD). Materials and Methods: PD model was developed by 4 int...
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Neurodegeneration refers to a condition of neuronal death occurring as a result of progressive disease of long term. It involves degeneration of circumscribed group of neurons that may be functionally or neuroanatomically connected. Parkinson’s disease (PD) is a chronic, progressive neurological disorder. Recent studies have indicated that a part of active compounds extracted from herbal medici...
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Background and Objective: Chronic diabetes mellitus (DM) leads to cardiovascular dysfunction. Diosgenin is a natural steroidal saponin with cardiovascular protective potential. In this research study, the beneficial effect of diosgenin was evaluated on some markers of oxidative stress in cardia tissue of streptozotocin (STZ)-diabetic rats. Materials and Methods: Male Wistar rats (n = 28) were ...
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Parkinson's disease (PD) is a neurodegenerative disorder, characterized by hypokinesia, but also mood and cognitive disorders. Neuropathologically, PD involves loss of nigrostriatal dopamine (DA) and secondary non-dopaminergic abnormalities. Inflammation may contribute to PD pathogenesis, evident by increased production of pro-inflammatory cytokines. PD onset has been positively associated with...
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ژورنال
عنوان ژورنال: Tropical Journal of Pharmaceutical Research
سال: 2016
ISSN: 1596-9827,1596-5996
DOI: 10.4314/tjpr.v15i4.14